Castration and diabetes

PART IV: WELFARE IMPLICATIONS OF CURRENT METHODS OF CASTRATION AND TAIL DOCKING Castration by elastration (the rubber ring method) Short scrotum castration Immunocastration Surgical castration Clamp (bloodless) castration

Exogenous Testosterone, Finasteride and Castration Effects on Testosterone, Insulin, Zinc and Chromium in Adult Male Rats

Background: Although effects of trace elements on secretion of sex steroids and insulin have been studied, the effects of these hormones on serum level of trace elements have been rarely investigated. The aim of the present study was to evaluate the effect of testosterone and finasteride administration and castration on serum levels of testosterone, insulin, zinc and chromium. Methods: Male adu...

Castration-resistant Prostate CanCer

• Objective: To review therapeutics for castrationresistant prostate cancer (CRPC). • Methods: Literature review. • Results: Targeting of androgen-dependent pathways in CRPC post-chemotherapy has been shown to improve survival with the lyase inhibitor abiraterone and lead to PSA and objective responses with an androgen receptor antagonist (MDV3100). However, the addition of bevacizumab to docet...

Ovary transplanted to spleen in rats: the effect of unilateral castration, pregnancy, and subsequent castration.

The transformations that take place in the rat ovary that has been transplanted to the spleen of a castrate rat appear to be the result of an altera tion in the normal endogenous hormone pattern. The exact nature of this alteration has thus far only partially been clarified, but at least two possi bilities must be considered. The first is that con tinuous stimulation of the intrasplenic ovary b...

Tail docking and castration of lambs

Freedom from pain and physical distress is widely accepted as being a critical part of animal welfare. However, in order to minimize suffering by the animal we must first devise a scale with which to assess the degree of pain that it is feeling. There have been several important developments in animal research in the last twelve months pertaining to pain evaluation in animals. The aim of each o...